Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

By Nathalie Q. Balaban, Ulrich S. Schwarz, D. Riveline, P. Goichberg, Gil Tzur, Ilana Sabanay, D. Mahalu, Shmuel Safran, A. Bershadsky, L. Addadi and 1 more. Nature Cell Biology, 2001

2,187 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/9fbd42455592951d47f6d227cf030ad89816295b

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Citations in the corpus

Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, background): “(7,8,12,24), and these changes in turn can alter the assembly state of the cytoskeleton and the tension imposed on it by activated myosins or other motors.”
Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Fluorescence microscopy has revealed that focal complexes mature into FAs in response to mechanical tension on an elastic micropatterened substrate (Balaban et al. 2001).”
Tensegrity I. Cell structure and hierarchical systems biology (2003, background): “, 1981) or quantifies cell-generated forces (Kolodney and Wylomerski, 1992; Pelham and Wang, 1997; Wang et al., 2001; Balaban et al., 2001).”
Blebs lead the way: how to migrate without lamellipodia (2008, background): “Focal adhesion formation can be activated by tensio”
Tensegrity II. How structural networks influence cellular information processing networks (2003, background): “Cytoskeletal restructuring in response to external stress through integrins also normally requires maintenance of cytoskeletal tension generation (i.e. cellular prestress) (Chicurel et al., 1998b; Wang et al., 2001a; Balaban et al., 2001).”
Focal Contacts as Mechanosensors (2001, methodology): “5 nN per m2 of focal contact area, as measured using elastic micropatterned substrate (Balaban et al., 2001).”
Mechanical control of stem cell differentiation (2008, background): “In parallel, the actin cytoskeleton contributes to the mechanical forces within the system due to the pulling action of myosin motors (principally non-muscle myosin II) on actin filaments, which result in the production of tensile forces against the extracellular matrix (Pelham and Wang, 1999; Balab”
Engineering microscale topographies to control the cell–substrate interface (2012, background): “The size of the FAs has been shown to be directly correlated with the traction force applied, when FA area is >1 μm2 [177,179].”
Actin stress fibers – assembly, dynamics and biological roles (2012, background): “Inhibition of myosin-II-promoted contractility leads to a decrease in focal adhesion size (Balaban et al., 2001; ChrzanowskaWodnicka and Burridge, 1996; Helfman et al., 1999), whereas applying mechanical force to the adhesions increases their size in a myosin-II-independent manner (Riveline et al.,…”
The relationship between force and focal complex development (2002, background): “5 nN/ m(2) (Galbraith and Sheetz, 1997; Balaban et al., 2001; Beningo et al., 2001), perhaps because a focal complex may have fewer structural components than a focal adhesion (Geiger et al.”
Dynamics of cell orientation (2007, neutral): “This contractile force pattern is generated by active interaction of the myosin II molecular motors with the actin cytoskeleton resulting in stress fibres that connect focal adhesions on opposite sides of the cel”
Focal adhesion regulation of cell behavior. (2004, background): “Balaban et al. [166] simultaneously measured cell displacements and focal adhesions (visualized by vinculin:GFP) to demonstrate that increased force is correlated with increased focal adhesion formation.”
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. (2005, background): “…in the number, size, and stability of integrin-based adhesions in different cell types [Entschladen and Zanker, 2000], and it seems probable that large focal adhesions characteristic of fibroblasts on stiff surfaces do not form nor could they function on soft gels [Balaban et al., 2001].”