Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4.

By Michael J. Axtell, B. Staskawicz. Cell, 2003

845 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9f9634e7ca8f04b8c8cc8f0733223f2b7cd53798

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Citations in the corpus

Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. (2005, background): “This idea is known as the guard model (24, 81), and it is the subject of intense investigation (7, 8, 74, 75, 78, 79, 101).”
Intracellular innate immune surveillance devices in plants and animals (2016, background): “M. J. Axtell, B. J. Staskawicz, Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2directed elimination of RIN4.”
A Novel Role for the TIR Domain in Association with Pathogen-Derived Elicitors (2007, methodology): “For example, Arabidopsis RPM1 interacts with the host protein RIN4 through its aminoterminus [20]; RIN4 in turn also interacts with RPM19s Avr elicitor AvrRpm1.”
The role and regulation of programmed cell death in plant–pathogen interactions (2004, background): “…RPM1 and RPS2 as well as the Avr protein AvrB. rps2 – mutants expressing avrRpt2 have no RIN4 protein Reduced expression in Arabidopsis leads to decreased HR upon infection with P. syringae/avrRpm1 and constitutive activation of cell death (Mackey et al., 2002; Axtell and Staskawicz, 2003).”
Are innate immune signaling pathways in plants and animals conserved? (2005, background): “Published data have provided compelling evidence for the latter scenario and have explained how plants can potentially recognize a diverse set of pathogens and pathogen-specific molecules using a relatively limited number of pathogen-receptor”
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. (2007, background): “Several plant proteins are known to interact with P. syringae effectors (Mackey et al., 2002; Axtell and Staskawicz, 2003; Mackey et al., 2003; Shao et al., 2003; Nomura et al., 2006).”
Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function[OPEN] (2018, background): “The NLRs ZAR1 and Prf each interact with multiple host proteins; by contrast, RPM1 INTERACTING PROTEIN4 (RIN4) is a host protein that interacts with multiple NLRs. RIN4 forms complexeswith the NLRsRPS2 andRPM1 (Axtell and Staskawicz, 2003; Mackey et al., 2002).”
Host-microbe interactions: shaping the evolution of the plant immune response. (2006, neutral): “RPM1 and RPS2 have each been shown to physically associate with RIN4 in planta (Axtell and Staskawicz, 2003; Mackey et al., 2002).”
From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors (2008, background): “RIN4 is targeted by AvrRpm1 and AvrRpt2 for phosphorylation and degradation, respectively (Mackey et al., 2002; Axtell and Staskawicz, 2003), but it is unknown if and how these modifications benefit pathogen virulence.”
Plant immunity: towards an integrated view of plant–pathogen interactions (2010, background): “syringae effectors AvrB, AvrRPM1 and AvrRpt2 through different molecular strategie”
How do plants achieve immunity? Defence without specialized immune cells (2012, background): “By contrast, the activity of AvrRpt2 on RIN4 is more direct, as RIN4 is cleaved by this bacterial cysteine protease, resulting in RPS2 activatio”
Plant NBS-LRR proteins in pathogen sensing and host defense (2006, background): “However, AvrRpm1, AvrB and AvrRpt2 all physically associate with another plant protein, RIN4 (refs”
Elicitors, effectors, and R genes: the new paradigm and a lifetime supply of questions. (2007, background): “This function of AvrRpt2 results from its degradation of RIN4, which is required for accumulation and function of RPM1 (13, 95, 110).”