Crystal structure of rhodopsin: A G protein-coupled receptor.

By Krzysztof Palczewski, T. Kumasaka, T. Hori, C. Behnke, H. Motoshima, B. A. Fox, I. L. Trong, D. Teller, T. Okada, R. Stenkamp and 2 more. 2000

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Multi-State Modeling of G-protein Coupled Receptors at Experimental Accuracy (2021, background): “Experimental structures of GPCRs are available since the first GPCR structure, for bovine rhodopsin, was resolved in 2000.(21) The”
A Structural Framework for GPCR Chemogenomics: What's In a Residue Number? (2018, neutral): “The aligned structures are Rhodopsin (PDB: 1F88 [21], 5DGY [22] co-crystallized with Arrestin-1), β1 (PDB: 2Y00 [23]), β2 (PDB: 3SN6 [24] co-crystallized with trimeric Gs-protein), H1 (PDB: 3RZE [25]), CXCR4 (PDB: 3ODU [26]), CCR2 (PDB: 5T1A [27]), GCGR (PDB: 4L6R [28], 5EE7 [29]), CRF1 (PDB: 4K5Y [”
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors (2004, methodology): “Receptor model The published bovine rhodopsin structure was used as a template for generating a partial GPR91 structure mode”
Biophysical dissection of membrane proteins (2009, background): “But when the structure of bovine rhodopsin, a true GPCR, was determine”
RCSB Protein Data Bank: Enabling biomedical research and drug discovery (2019, background): “The landmark structure of bovine rhodopsin (PDB 1f88) gave the first view of the class in 2000, 29 and initially, GPCR structure depositions to the PDB were restricted to the Rhodopsin subfamily, many of them crystallized using lipidic mesophases.”
G protein coupled receptor structure and activation. (2007, background): “8 Å [22] and subsequent improvements have led to diffraction at 2.”