Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

By Weihai He, F. J. Miao, Daniel C.-H. Lin, R. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, H. Tian, L. Ling. Nature, 2004

897 citations recorded by the source corpus.

Subfields: Biochemistry, Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/869229b2771ab13c140d0c85fa40b4b0d196c0bb

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Citations in the corpus

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury. (2016, background): “In addition, extracellular succinate can activate the G protein-coupled receptor GPR91, which may be a relevant sensor responding to the succinate released into the extracellular space by cell death or lysis following ischemia (He et al., 2004).”
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. (2005, background): “…inﬁltrating form. protein-coupled receptor, suggesting that succinate can also It is frequently hypothesized in the literature that ROS gener-be released from cells under some physiological/pathological ation due to SDH mutations may mediate HIF-1 (cid:1) induction circumstances (He et al., 2004).”
Anatomical profiling of G protein-coupled receptor expression (2008, positive): “The concentration of succinate in plasma has been reported at 5–125 mM, a range that surrounds the EC50 for Gpr91 activation (He et al., 2004) and the IC50 for inhibition of lipolysis in WAT (Figure 4).”
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. (2011, background): “Furthermore, succinate can induce hypertension in animals when administered intravenously [145]; it is unclear whether this effect occurs in humans, but if it does, this may limit its clinical application.”
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “…CHO, Chinese hamster ovary; SCG, superior cervical 2004), but it is now firmly established that it is actually a receptor for -ketoglutarate (He et al., 2004; Qi et al., 2004; Suarez Gonzalez et al., 2004), as was also recently underlined in a report by the Subcommittee (Abbracchio et al.,…”
The Metabolic Signature of Macrophage Responses (2019, background): “As already discussed, the succinate receptor SUCNR1/GPR91 is known to play a role in several diseases including diabetic retinopathy (108), diabetic renal disease (114), hypertension (113, 115), atherothrombosis (116), neuroinflammation (111), rheumatoid arthritis (114), and metabolic dysfunctions (”
Metabolite Profiles and the Risk of Developing Diabetes (2011, neutral): “, metabolites may have unanticipated roles as regulatory signals with hormone-like function”
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, neutral): “EC50 value of succinate on human and mouse GPR91 is 56 and 28 mM, respectively (He et al., 2004).”