Re-emergence of fatal human influenza A subtype H5N1 disease

By J. Peiris, WC Yu, C. Leung, C. Cheung, Wf Ng, J. Nicholls, T. Ng, K. Chan, S. Lai, W. Lim and 2 more. The Lancet, 2004

875 citations recorded by the source corpus.

Summary Human disease associated with influenza A subtype H5N1 reemerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflam-matory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/9f3d68afac620f0f6c4d02fed6570b61bcea0e2a

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In Epidemiology

In Infectious Diseases

Shizuo Akira

Citations in the corpus

The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes (2015, neutral): “We compared some other cytokines and chemokines mediators in the plasma of patients with avian influenza H7N9, H5N1, and swine-origin influenza virus infections as well as SARS-CoV infections reported previously.”
Influenza: lessons from past pandemics, warnings from current incidents (2005, background): “In early 2003, an H5N1 virus infected a family in Hong Kon”
H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice (2008, background): “Elevated levels of certain chemokines and cytokines have been associated with high viral load and severe disease in H5N1 virus infected patients [26,31].”
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia (2006, background): “Postmortem examinations have not shown evidence of extrapulmonary infection, but revealed reactive hemophagocytosis (which is believed to be a cytokine-driven condition) as the most prominent featur”
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury (2008, background): “The pathology of ARDS in SARScoronavirus (Lew et al., 2003) and H5N1 avian influenza virus infections (Beigel et al., 2005; Peiris et al., 2004) is characterized by accumulation of inflammatory cells, edema formation, and a marked increase in cytokines.”
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, result): “Similar associations have been demonstrated in the context of influenza virus (21, 43, 206, 283), coronavirus (328), and parainfluenza virus (58) infections.”
Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “The human H3N2 (unreassorted) virus is known to be endemic in pigs in southern China (169).”
Into the Eye of the Cytokine Storm (2012, background): “The rapid and intense nature of the host inflammatory response is the suspected cause of severe lung damage (116).”