Influenza: lessons from past pandemics, warnings from current incidents

By T. Horimoto, Yoshihiro Kawaoka. Nature Reviews Microbiology, 2005

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Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge (2010, background): “In recent years, however, certain strains of highly pathogenic avian influenza (H5N1) have been identified as the causative agents of a severe form of flu in humans, and it has been suggested that these have the potential to cause a pandemic (2).”
Antiviral agents active against influenza A viruses (2006, background): “The H + ions are imported through the M2 (matrix 2) channels 10 ; the transmembrane domain of the M2 protein, with the amino-acid residues facing the ion-conducting pore, is shown in FIG. 3a (REF. 11 ).”
Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “The viral and host factors that determine host restriction are poorly understood (83, 84, 116, 156, 249) and are believed to be determined by multiple viral genetic determinants including the viral HA and NA genes as well as other internal genes such as the nucleoprotein and the PB2 genes.”