A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence

By D. Chinchilla, Cyril Zipfel, S. Robatzek, Birgit Kemmerling, T. Nürnberger, Jonathan D. G. Jones, G. Felix, T. Boller. Nature, 2007

1,876 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/9e2b0bad256f828b6327873353af5575945c9415

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Citations in the corpus

Pattern-recognition receptors in plant innate immunity. (2008, background): “Interestingly, in all these examples, BAK1 function appears to be BR-independent [40 ,41 ,42 ,43 ].”
Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity. (2008, methodology): “The bak1-1 mutant is in the Ws background, which does not have a functional FLS2 (Li et al., 2002), and bak1-3 (Salk_034523) and bak1-4 (Salk_116202) mutants are in the Col-0 background (Chinchilla et al., 2007; He et al., 2007a; Heese et al., 2007; Kemmerling et al., 2007).”
Hormone crosstalk in plant disease and defense: more than just jasmonate-salicylate antagonism. (2011, background): “BAK1 is also involved in FLS2 and EFR signaling (32), two LRR-RLKs involved in perception of pathogen molecules.”
The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. (2014, background): “Split-luciferase complementation assays in Nicotiana benthaminana indicated that both BIK1 and FLS2, but not BAK1, can interact with RbohD in vivo (Figures 2B and S1B), indicating that RbohD specifically interacts with the unstimulated FLS2 receptor complex.”
The Arabidopsis Leucine-Rich Repeat Receptor–Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens[W] (2011, background): “First, we verified that the previously reported flg22induced FLS2-BAK1 interaction (Chinchilla et al., 2007; Heese et al., 2007; Schulze et al., 2010) could be recapitulated in N. benthamiana.”
Of PAMPs and Effectors: The Blurred PTI-ETI Dichotomy[OA] (2011, background): “By contrast, interfamily transfer of PAMP receptors appears to be more successful, as exemplified by the transfer of the PRRs EFR for bacterial EF-Tu and FLS2 for bacterial flagellin from Arabidopsis toN. benthamiana and tomato (Chinchilla et al., 2006; Zipfel et al., 2006; Lacombe et al., 2010).”
Signaling mechanisms in pattern-triggered immunity (PTI). (2015, neutral): “around 10–14min (Chinchilla et al., 2007; Nuhse et al., 2007; Ranf et al., 2011).”
Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. (2010, background): “The flg22 treatment induced a strong interaction between FLS2 and BAK1, as previously reported (Chinchilla et al., 2007; Heese et al., 2007), and coexpression of either WT BIK1 or the BIK1 mutant did not inhibit FLS2-BAK1 association (Figure S4E), suggesting that a BIK1-FLS2 dissociation is not a pr”
Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome. (2017, background): “Plasma membrane located pattern recognition receptors, FLS2 and EFR, belong to the LRR-RLK subfamily XII and require SERK (LRR-RLK subfamily II) co-receptors (Chinchilla et al., 2007; Gómez-Gómez and Boller, 2000; Roux et al., 2011; Zipfel et al., 2006).”
Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function[OPEN] (2018, background): “The flg22 peptide binds directly to FLS2 triggering the recruitment of BRI1-ASSOCIATEDRECEPTORKINASE (BAK1), aRLK (Chinchilla et al., 2007).”