Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.

By Libo Shan, Ping He, Jianming Li, Antje Heese, Scott C. Peck, T. Nürnberger, G. Martin, Jen Sheen. Cell Host and Microbe, 2008

594 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/e9a48a21316d5b4e60d29f1565382efdba8c4bc2

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In Plant Science

1. Cyril Zipfel
2. Olivier Voinnet
3. Heribert Hirt
4. J. Rathjen
5. P. Dodds
6. Alok Kumar Pandey
7. Subhadeep Chatterjee
8. J. Colcombet

Citations in the corpus

• Brassinosteroid signal transduction from receptor kinases to transcription factors. (2010, background): “The transgenic plants overexpressing the bacterial effector AvrPto show dwarf phenotypes that mimic weak bri1 mutants, and AvrPto and AvrPtoB interact with BAK1, leading to disruption of FLS2-BAK1 association (78).”
• Signaling in Plant-Microbe Interactions (2013, background): “syringae effectors such as AvrPto and AvrPtoB, target the FLS2–BAK1 complex (Gohre et al. 2008; Shan et al. 2008).”
• Role of plant hormones in plant defence responses (2009, background): “Recently, Shan et al. (2008) demonstrated that bacterial effectors, AvrPto and AvrPtoB, target BAK1 and prevent the flagellin induced FLS2-BAK1 interaction, thereby impeding the initiation of PAMP-signaling.”
• Signaling mechanisms in pattern-triggered immunity (PTI). (2015, background): “In addition, BAK1 is a convergent target of AvrPto, AvrPtoB, and HopF2 (Shan et al., 2008; Cheng et al., 2011; Wu et al., 2011; Zhou et al., 2014).”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, unknown): “AvrPto blocks MAMP signalling by binding the kinase domain of the RLKs FLS2, EFR, CERK1, and BAK1, while AvrPtoB targets FLS2 for degradation (Göhre and Robatzek, 2008; Shan et al., 2008; Xiang et al., 2008; Gimenez-Ibanez et al., 2009b).”
• Plant immunity: towards an integrated view of plant–pathogen interactions (2010, background): “As such, BAK1 is a central regulator of plant immunity and consequently the target of several pathogen virulence effector molecule”
• Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity (2011, methodology): “Protoplast transient assay was carried out as described (29).”
• The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid. (2012, background): “The central domain of AvrPtoB has binding affinity for FLS2 and its signaling partner BAK1.”
• Roles of plant small RNAs in biotic stress responses. (2009, background): “Although this result could suggest the existence of an as yet uncharacterized membranous pool of miRNA-processing factors, an alternative explanation lies in the interaction of AvrPto with the plasma membrane protein BAK1 (BRI1-associated receptor kinase 1) (66).”
• Plant pattern recognition receptor complexes at the plasma membrane. (2012, background): “Intriguingly, PGN responses seem to depend on both CERK1 and BAK1 in Arabidopsis [26 ,46], which is in contrast to the strict BAK1-independency of CERK1mediated chitin responses in Arabidopsis [27,46,48].”
• Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. (2010, background): “Shan et al. (2008) suggested that both AvrPto and AvrPtoB target BAK1.”