The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity.

By Lei Li, Meng Li, Liping Yu, Zhaoyang Zhou, Xiangxiu Liang, Zixu Liu, Gaihong Cai, Liyan Gao, Xiaojuan Zhang, Yingchun Wang and 2 more. Cell Host and Microbe, 2014

730 citations recorded by the source corpus.

The Arabidopsis immune receptor FLS2 senses the bacterial flagellin epitope flg22 to activate transient elevation of cytosolic calcium ions, production of reactive oxygen species (ROS), and other signaling events to coordinate antimicrobial defenses, such as stomatal closure that limits bacterial invasion. However, how FLS2 regulates these signaling events remains largely unknown. Here we show that the receptor-like cytoplasmic kinase BIK1, a component of the FLS2 immune receptor complex, not only positively regulates flg22-triggered calcium influx but also directly phosphorylates the NADPH oxidase RbohD at specific sites in a calcium-independent manner to enhance ROS generation. Furthermore, BIK1 and RbohD form a pathway that controls stomatal movement in response to flg22, thereby restricting bacterial entry into leaf tissues. These findings highlight a direct role of the FLS2 complex in the regulation of RbohD-mediated ROS production and stomatal defense.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/47c484c146b97fd2b8040f25f2eaf9b1c90ba749

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

Citations in the corpus

Reactive oxygen species, abiotic stress and stress combination. (2017, background): “compounds, alkaloids, tocopherol and carotenoids, and accumulation of osmoprotectants such as proline, glycine betaine, trehalose and sucrose (Keles and € Oncel, 2002; Rizhsky et al., 2002; Rizhsky et al., 2004; Giraud et al., 2008; Vile et al., 2012; Prasch and Sonnewald, 2013; Rasmussen et al., 20”