Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging

By T. Seeman, Bruce S. McEwen, J. Rowe, Burton H. Singer. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,352 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/9e0f36d6b90233e9e480e965b1490e4069cc6344

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. J. Wingfield
2. Sonia J. Lupien
3. Bruce S. McEwen
4. R. Juster
5. Dennis S. Charney
6. George M. Slavich
7. W. Goymann
8. E. Epel

In Physiology

1. Bruce S. McEwen
2. J. Wingfield
3. W. Goymann
4. Sonia J. Lupien
5. R. Juster
6. Howard Bergman
7. Kenneth Rockwood
8. Dennis S. Charney

Citations in the corpus

• Positive health: connecting well-being with biology. (2004, background): “Our implicit model construes health problems as the downstream outcome of biomarkers that are in zones of elevated risk, and in other longitudinal studies of ageing we have shown that higher allostatic load (which combines risk across multiple physiological systems) is a significant predictor of inc”
• Linking Perceived Unfairness to Physical Health: The Perceived Unfairness Model (2006, background): “As suggested by allostatic load theory, there may be a cumulative cost of adaptation (Seeman et al., 2001).”
• Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. (2002, background): “However, the original measures and original “allostatic load score” has provided useful information that supports the usefulness of this type of measurement in predicting changes over time and influences of such factors as social support, income, education and positive or negative influences of rela”
• Work Stress and Employee Health (2013, background): “…the Al model proposes that continued overstimulation of primary mediators leads to dysregulation in secondary mediators and then to tertiary outcomes, but this sequence has proven difficult to validate empirically (Goldman, Turra, Glei, Seplaki, lin, & Weinstein, 2006; Seeman et al., 2001).”
• Benefit Finding and Physical Health: Positive Psychological Changes and Enhanced Allostasis (2008, background): “There is growing evidence that biological profiles indicative of allostatic load are associated with negative health outcomes (e.g., Seeman et al., 2001), and that individuals who show more pronounced and persistent physiological reactivity to stress are at greater risk for disease, particularly…”
• Advances in Continuous Traumatic Stress Theory: Traumatogenic Dynamics and Consequences of Intergroup Conflict: The Palestinian Adolescents Case (2013, background): “Elevated continuous or prolonged, chronic coping demands sets in motion a cascade of physiological changes that contribute to the development of chronic illnesses, including hypertension, cardiac disease, diabetes, stroke, and psychiatric disorders (Seeman et al., 2001).”
• Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “Most importantly, higher AL was related to increased risk of allcause mortality (Seeman et al., 2001).”
• What a drop can do: Dried blood spots as a minimally invasive method for integrating biomarkers into population-based research (2007, methodology): “…are used in conjunction with non-DBS biomarkers (e.g., salivary cortisol, blood pressure, anthropometric measures) to provide summary assessments of health across multiple physiological systems, analogous to current applications of the concept of allostatic load (McEwen 1998; Seeman et al. 2001).”
• More than a feeling: A unified view of stress measurement for population science (2018, background): “Fortunately, although diagnosable disease does not occur until later in life, there are several reliable indices of early damage to regulatory systems, allostatic load (Hwang et al., 2014; Robertson et al., 2017; Seeman et al., 2001), and cellular aging such as inflammation, telomere length, and epi”
• Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS) (2008, background): “[146,279].”
• Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “Thus, these data are consistent with the hypothesis that although modest abnormalities in a single physiological system may not be predictive of poor health outcome, the cumulative effect of multiple abnormalities in the physiological system is prognostic of poor physical health (11, 138).”