Sex, stress and the hippocampus: allostasis, allostatic load and the aging process.

By Bruce S. McEwen. Neurobiology of Aging, 2002

763 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/4d059ab700b0d95b56c8a3f16696ca67801c633f

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Citations in the corpus

Stress and Memory: Behavioral Effects and Neurobiological Mechanisms (2007, background): “Since chronic stress was originally reported to damage hippocampal structure (McEwen [128, 129]), the possibility that chronic stress affects hippocampal-dependent learning has been extensively tested over the past years.”
Enrichment Effects on Adult Cognitive Development (2008, background): “can have profound negative effects on brain structure and function (Cacioppo, Hughes, Waite, Hawkley, & Thisted, 2006; McEwen, 2002; Sapolsky, 1992).”
Assessing the Importance of Natural Behavior for Animal Welfare (2006, background): “However, on the long-term these responses may represent a risk by its wear and tear effects (so called ‘‘allostatic load’’; e.g., McEwen 2002 ).”
STRESS IN FREE-RANGING MAMMALS: INTEGRATING PHYSIOLOGY, ECOLOGY, AND NATURAL HISTORY (2005, background): “A recent review by McEwen (2002) discusses individual differences in vulnerability to allostatic load, stress, and their role in aging.”
Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. (2005, background): “The exact cause for these regional differences is unknown and multiple hypotheses abound [58–60,77,91,92] , although these theories rarely speak to regional variability with age [60,69].”
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms (2006, background): “However, under chronic stress most physiological systems are negatively affected by prolonged exposure to glucocorticoids and catecholamine”
Differential aging of the brain: patterns, cognitive correlates and modifiers. (2006, neutral): “, 1987 ; McEwen , 2002b ) , and stress hormones released on acute or chronic schedule are detrimental to memory performance at all ages ( Lupien et al .”
Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum (2012, background): “At the cellular level, the key effects of stress are to suppress ongoing neurogenesis in the dentate gyrus (DG) and to provoke the remodeling of dendrites in the cornu ammonis (CA), particularly the CA3 subfield (36, 37).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “Parsimoniously, this region, included in the limbic-cognitive system, is part of an integrated network involved in learning and memory, attentional processes, motivational states, and emotion (68, 135, 136, 227, 352, 484).”
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “McEwen (2) extended this definition to include the concept of a set point that changes because of the process of maintaining homeostasis (2).”
The Aging Cortical Synapse: Hallmarks and Implications for Cognitive Decline (2012, neutral): “As in the PFC, stress and ageing both affect hippocampal structure and function, as recently reviewed elsewher”