The genetics of autism

By M. B. Lauritsen, H. Ewald. Acta Psychiatrica Scandinavica, 2001

931 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9d6dcbb385677ffbf55f77cb497439657d438572

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Daniel H. Geschwind
2. Pat Levitt
3. Mu Yang
4. Matthew K. Belmonte
5. S. Webb
6. E. Hollander
7. Daniel P. Kennedy
8. Ralph Adolphs

In Genetics

1. Daniel H. Geschwind
2. Pat Levitt
3. Mu Yang
4. Matthew K. Belmonte
5. Daniel P. Kennedy
6. Ralph Adolphs

In Molecular Biology

1. Daniel H. Geschwind
2. Pat Levitt
3. Daniel P. Kennedy
4. Ralph Adolphs

Citations in the corpus

• Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. (2005, background): “The etiology of these disorders is not completely understood, but twin and family studies suggest that genetic factors play a substantial causal role; the concordance rate is found to be at least 36 percent for monozygotic twins and is expected to be about 3 percent for dizygotic twins (7).”
• Autism and Abnormal Development of Brain Connectivity (2004, background): “The combination of this broad variation of phenotypes and a 60 –90% concordance rate in identical twins (Bailey et al., 1995) suggests a large number of genetic and environmental biasing factors (Muhle et al., 2004).”
• Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders (2003, background): “Of interest, genetic syndromes such as Prader–Willi (15q 13-14) have oxytocin abnormalities and a polypeptide that shares this chromosomal site influences pro-hormone convertace (PC2), whose gene (20p 11-1-11-2) is proximal to the oxytocin gene, and chromosomal abnormalities at this site have been i”
• Pten regulates neuronal arborization and social interaction in mice. (2006, neutral): “Many genetic factors have been implicated in ASD, including 15q11-q13 duplication and mutations responsible for fragile X mental retardation syndrome (FMR1) and Rett syndrome (Andres, 2002; Muhle et al., 2004).”
• Rare de novo and transmitted copy-number variation in autistic spectrum disorders. (2011, neutral): “Autism spectrum disorders (ASDs) are among the most genetically determined of developmental and cognitive abnormalities, with concordance between identical twins reported at nearly 90% in some studies (Muhle et al., 2004; Rosenberg et al., 2009).”
• Autism‐like behavioral phenotypes in BTBR T+tf/J mice (2008, methodology): “1a) as pre- viously reported (Crawley et al. 2007; Moy et al. 2004, 2007; Nadler et al. 2004).”
• Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006, background): “However, despite intense research effort, no single gene or specific environmental factor has been reproducibly identified [Muhle et al., 2004].”
• Autism spectrum disorders: developmental disconnection syndromes (2007, background): “If one considers this clinical heterogeneity, the lack of correlation between occurrence of different deficits (including the core features) [6], and also the genetic heterogeneity [7 ,8], it might be more constructive to think of ASDs as ‘the autisms’ than as a unitary syndrome (Figure 1).”