Autism spectrum disorders: developmental disconnection syndromes

By Daniel H. Geschwind, Pat Levitt. Current Opinion in Neurobiology, 2007

1,460 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/064dd1808f29579f1c6347dcd5f447813db8d6c7

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Citations in the corpus

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “Therefore, a characteristic of ASD appears to be a relative inability to integrate pieces of information into coherent wholes (317, 346, 416, 417).”
Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009, neutral): “This may result in further altered long-range connectivity [80, 81], vital for communication between neocortical modules and hemispheres [74, 82 – 85].”
The Construct of the Multisensory Temporal Binding Window and its Dysregulation in Developmental Disabilities (2014, background): “…disconnection syndrome or a connectopathy, in which the core deficits are founded in weaknesses in connectivity across brain networks and that have been seen in both structural and functional connectivity studies (Geschwind & Levitt, 2007; Just et al., 2004, 2007; Melillo & Leisman, 2009).”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Thus, as predicted by theoretical considerations (Bienenstock et al, 1982; Stent, 1973), LTP and LTD mechanisms appear to be critically involved in early neural circuit development and it is not difficult to imagine how disruption in these mechanisms might contribute to a host of neurodevelopemental”
The Cerebellum, Sensitive Periods, and Autism (2014, background): “In Joubert syndrome, 25% of cases are diagnosed with ASD (Geschwind and Levitt, 2007).”
The social brain in psychiatric and neurological disorders (2012, positive): “Autism spectrum disorders (ASD) are a collection of neurodevelopmental disorders [80], with estimated prevalence of approximately 1:100, a substantial genetic component, and impairments in social interaction and communication, together with restricted interests and often stereotyped and repetitive b”
Big data approaches to decomposing heterogeneity across the autism spectrum (2018, background): “notype [9, 10], throughout development [16, 38], and manifesting as important clinical differentiation (e.”
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities and core autism-related deficits (2011, positive): “, 2010), supporting the notion that the deficits in cognition and behavior associated with ASD are most likely the result of a developmental disconnection (Geschwind and Levitt, 2007).”
Dendritic spine pathology in neuropsychiatric disorders (2011, result): “Such findings are consistent with an emerging hypothesis that the brains of individuals with ASD are characterized by hyperconnectivity in local circuits and hypoconnectivity between brain region”