Autism‐like behavioral phenotypes in BTBR T+tf/J mice

By H. McFarlane, G. Kusek, Mu Yang, J. L. Phoenix, V. J. Bolivar, J. Crawley. Genes, Brain and Behavior, 2008

781 citations recorded by the source corpus.

Subfields: Aging, Cognitive Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/f8474160667fe63508022add4976976dd617ab2f

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Citations in the corpus

Mechanisms underlying microbial-mediated changes in social behavior in mouse models of Autism Spectrum Disorder (2018, positive): “The BTBR T+ Itpr3tf/J (BTBR) inbred mouse line exhibits the core ASD symptoms, including abnormal social behavior (McFarlane et al., 2008; Scattoni et al., 2008).”
Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism (2012, background): “Self-grooming is also increased in several other mouse strains with relevance to autism (BTBR, and Fmr1, MeCP2 and CNTNAP2 KO mice) (McNaughton et al., 2008; McFarlane et al., 2008; Chao et al., 2010; Peñagarikano et al., 2011).”
Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009, positive): “Interestingly, among several inbred strains [86], it is the acallosal BTBR T+tf/J mouse that most closely exhibits behavioral changes specific to autism, including reduced social approach, altered ultrasonic vocalization, and resistance to change in routine [87].”
Automated home-cage behavioural phenotyping of mice. (2010, background): “For example, reported tests of grooming behaviour span time scales of minute”
Automated Three-Chambered Social Approach Task for Mice (2011, background): “Number of transitions across chambers offers a built-in control measure of exploratory locomotion (Crawley, 2007b, 2008; McFarlane et al., 2008; Moy et al., 2008b, 2009; Yang et al., 2009, 2011a; Silverman et al., 2010 a,b).”
Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression (2009, background): “Finally, mouse grooming behavior may also have a significant application in the study of human brain disorders (10, 13, 44, 46).”
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, methodology): “To test the behavioral effects of 5AV and taurine, we employed the BTBR T+ tf/J (BTBR) mouse model that displays ASD-related behavioral changes (McFarlane et al., 2008; Meyza and Blanchard, 2017; Moy et al., 2007; Silverman et al., 2010).”