Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing

By E. Snitkin, A. Zelazny, Pamela J. Thomas, F. Stock, D. Henderson, T. Palmore, J. Segre. Science Translational Medicine, 2012

904 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Endocrinology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/9d4dc0ce9f5e9ade283cee2458a21220bb967419

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Kathryn E. Holt
2. J. Pitout
3. Jongsik Chun
4. D. Alland
5. F. Tenover

In Endocrinology

1. Rebekah M. Martin
2. J. Pitout
3. Robert A. Bonomo
4. G. Peirano
5. M. Bachman
6. Amy Mathers

In Molecular Medicine

1. Kathryn E. Holt
2. Andrew D. S. Cameron
3. Rebekah M. Martin
4. J. Pitout
5. Robert A. Bonomo
6. G. Peirano
7. M. Bachman
8. N. Lerminiaux

Citations in the corpus

• Better Tests, Better Care: Improved Diagnostics for Infectious Diseases (2013, background): “breaks of infection due to resistant bacteria (eg, the NIH outbreak of multidrug-resistant gram-negative bacteria [55] and the cholera outbreak in Haiti [50]).”
• Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health (2015, background): “pneumoniae carbapenemase (KPC) gene as well as numerous other acquired AMR genes and has been responsible for hospital outbreaks on several continents (13, 26, 27).”
• Introducing EzBioCloud: a taxonomically united database of 16S rRNA gene sequences and whole-genome assemblies (2017, background): “Because genome sequences can be used for assessing suprageneric phylogeny, recognizing species [8] and differentiating clinical clones with few single nucleotide polymorphisms [11], it is evident that their use in the taxonomy of the Bacteria and Archaea will greatly improve not just taxonomy, but a”
• Horizontal transfer of antibiotic resistance genes in clinical environments. (2019, background): “Plasmid conjugation transfers novel genes, 417 thus is relatively easy to track by DNA sequencing and PCR (Boyd et al. 2015; Gorrie et al. 418 2018; Simner et al. 2018; Snitkin et al. 2012).”
• Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae (2018, background): “CR-Kp colonization can also trigger a clonal outbreak and newly colonized patients can develop fatal infections (Snitkin et al., 2012).”
• The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae (2015, background): “, months) after the identification of the initial index patient (151).”