The protein kinase B/Akt signalling pathway in human malignancy.

By K. M. Nicholson, N. Anderson. Cellular Signalling, 2002

1,740 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9d3a67c5cfb41e89c0e5339ecc38fe6267527bfc

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Citations in the corpus

Deregulated Akt3 Activity Promotes Development of Malignant Melanoma (2004, background): “NP_005456) and 84% and 78% identical to Akt1 and Akt2, respectively (13, 14).”
Activation of the PI3K/Akt pathway and chemotherapeutic resistance. (2002, background): “Phosphorylation of the forkhead family of transcription factors (AFX, FKHR, and FKHRL1) by Akt inhibits transcription of pro-apoptotic genes such as Fas-L, IGFBP1 and Bim (Datta et al., 1999; Nicholson and Anderson, 2002).”
PI3K-Akt pathway: Its functions and alterations in human cancer (2004, background): “A subset of PH domains preferentially binds to PI(3,4)P2 and PI(3,4,5)P3 over other PIs.”
Molecular mechanisms of drug resistance (2005, background): “Activation of PI3K generates phosphatidylinositol 3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt to the plasma membrane, where it is phosphorylated and activated by 3-phosphoinositide-dependent kinase1 (PDK-1) [222,223].”
Epidermal growth factor receptor: mechanisms of activation and signalling. (2003, background): “One of the best characterized targets of this second messenger is the Ser/Thr kinase Akt (PKB [185]), which binds to the lipid and is translocated to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) and possibly other kinases (reviewed by Ni”
Integrin-linked kinase: a cancer therapeutic target unique among its ILK (2005, background): “45 ), and its consecutive activation and stimulation of downstream anti-apoptotic pathways, such as activation of NF-κB, inhibition of forkhead transcription factors and inactivation of pro-apoptotic proteins such as BA”
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. (2016, background): “Ever since, three Akt subtypes including Akt1, Akt2 and Akt3 has been recognized [101].”
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005, background): “Misregulation of the Akt signaling pathway is a key cause of cancer (Black, 2000; Lawlor and Alessi, 2001; Nicholson and Anderson, 2002; Vivanco and Sawyers, 2002).”
High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway (2012, background): “The Akt is a serine/threonine protein kinase and functioning downstream of phosphatidylinositol 3-kinase in response to mitogen or growth factor stimulation [34].”
PI3K/Akt and apoptosis: size matters (2003, background): “…as a consequence of activation of the second messenger phospholipid kinase phosphatidylinositol 3-kinase (PI3K), but also defined a role for Akt in promoting cell survival in a variety of apoptotic paradigms (Brazil and Hemmings, 2001; Scheid and Woodgett, 2001, 2003; Nicholson and Anderson, 2002).”
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway (2008, background): “Specifically, the Akt/PKB pathway and members of the Bcl-2 survival family have been studied extensively and shown to play an important anti-apoptotic role in many cancers (Nicholson and Anderson, 2002; Sebolt-Leopold and Herrera, 2004).”