Deregulated Akt3 Activity Promotes Development of Malignant Melanoma

By Jill M. Stahl, Arati Sharma, M. Cheung, M. Zimmerman, J. Cheng, M. Bosenberg, M. Kester, L. Sandirasegarane, G. Robertson. Cancer Research, 2004

612 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/fa6f8cd6ec9a23ff2fcd50e2929f757802b15cac

How researchers see this paper

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In Molecular Biology

1. M. Wymann
2. Yardena Samuels
3. T. Waldman
4. Bernd Giese
5. Romina Marone
6. Vladimir Cmiljanović

Citations in the corpus

• Melanoma biology and new targeted therapy (2007, background): “, and the PI(3)K effector protein kinase B (PKB, also known as Akt) is overexpressed in up to 60p of melanoma”
• In brief (2011, neutral): “PI3K-Akt signaling is upregulated and contributes to tumorigenesis in 60% of advanced-stage melanomas (Stahl et al., 2003, 2004).”
• Oncogenic mutations of PIK3CA in human cancers. (2004, background): “For example, several studies have indicated that approximately sixty percent of melanomas contain activated AKT (most likely the Akt3 isoform) (Stahl et al. 2004; Bastian et al. 1998).”
• Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “This is seen in more than 50% of breast and prostate tumors, as well as in melanoma, endometrial, colorectal cancer and leukemia [145–148].”