The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

By John Hardy, D. Selkoe. Science, 2002

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration (2011, background): “The essential neuropathological character of Alzheimer's disease entails the aggregation and accumulation of intracellular and extracellular component”
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. (2003, background): “Astrogliosis is a prominent feature of AD neuropathology [1,3].”
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease (2002, background): “Its primacy has been manifested in the 'amyloid-cascade hypothesis', which posits that the accumulation of Aβ (resulting from overproduction, altered processing or a failure of clearance mechanisms) is the initiating molecular event that triggers neurodegeneration in sporadic and familial Alzheimer'”