Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1,020 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Mechanisms of tau-induced neurodegeneration (2009, neutral): “Consistent with this hypothesis, both intracerebral infusion of Ab in FTDP-17 tau mutation P301L-expressing transgenic mice, as well as crossing these animals with APPTg2576 mice (APP Swedish plus London mutations), were found to exacerbate neurofibrillary pathology [54, 104] and, in the triple tran”
The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal (2009, background): “degeneration has been seen is in the context of additional microtubule associated protein tau (MAPT) mutations (Lewis et al. 2001; Oddo et al. 2003), and in these cases, the MAPT mutations themselves lead to cell death (Lewis et al.”
Alzheimer’s disease: experimental models and reality (2017, background): “Of all of the models reported, only the 3xTg mouse model has been widely used in AD studies and is considered the most complete transgenic mouse model of AD pathology available [108].”
Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “Triple transgenic mice with mutant APP, PS1, and tau proteins develop Aβ deposition prior to the appearance of NFT pathology (Oddo et al. 2003).”