Intestinal label-retaining cells are secretory precursors expressing Lgr5

By S. Buczacki, H. Zecchini, A. Nicholson, R. Russell, Louis Vermeulen, Richard Kemp, D. Winton. Nature, 2013

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The intestinal crypt, a prototype stem cell compartment. (2013, background): “Winton and colleagues reassessed the nature of crypt LRCs by briefly expressing the stable chromatin marker histone 2B yellow fluorescent protein (YFP) throughout the crypt (Buczacki et al., 2013).”
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014, positive): “Small numbers of noncycling secretory progenitors located near the crypt bottom have recently been demonstrated to represent a noncycling ‘‘reserve’’ stem cell population (Buczacki et al 2013).”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Nevertheless, the precise lineage and hierarchy of the two types of ISCs in the intestinal epithelium are still under debate [164–166].”
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease (2018, background): “This may reflect recruitment of normally quiescent epithelial ‘‘label-retaining cells’’ (LRCs), that are recalled to the stem cell compartment following inflammation mediated injury (Buczacki et al., 2013).”
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Nonetheless, developmental plasticity may yet remain because early committed precursors can flexibly regain stem cell status upon tissue damage in vivo (43, 62, 93, 94) or Wnt3a treatment ex vivo, in some instances (62).”