The bright side of the glial scar in CNS repair

By A. Rolls, R. Shechter, M. Schwartz. Nature Reviews Neuroscience, 2009

658 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/3e04fe90503c92857071bcd9f01602b832989303

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. M. Schwartz
6. G. Martino
7. Alexei Verkhratsky
8. S. Pluchino

In Developmental Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. C. Farina
6. E. Colombo
7. M. Schwartz
8. G. Martino

In Pathology and Forensic Medicine

1. M. Sofroniew

Citations in the corpus

• Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “A small number of blood-derived monocytes have been observed to participate in the default tissue remodeling response in the CNS at late time points following injury, even in the absence of a breach of the bloodebrain barrier [129,130].”
• The biophysics of neuronal growth (2010, neutral): “field of spinal cord injury [242].”
• Astrocytes: Key Regulators of Neuroinflammation. (2016, background): “CNS injury triggers a process leading to scar formation, whose impact on tissue homeostasis is ambivalent, as inflammatory and neurotoxic mediators are produced at injury site but remain confined to that area thanks to the glial scar [4].”
• Astrocytes: a central element in neurological diseases (2016, background): “Numerous negative consequences of reactive astrogliosis were also demonstrated, in particular when it does not get resolved in time, and can thus become maladaptive [187].”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Macrophages and microglia were reported to support growth and survival of neurons (192).”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “Numerous undesired consequences of reactive astrogliosis have been demonstrated, in particular when astrocyte activation and reactive astrogliosis do not get resolved during the postacute stage or at the early chronic stage after the injury event (196).”