Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

By A. Tan, J. Baty, Lan-Feng Dong, Ayenachew Bezawork‐Geleta, B. Endaya, Jacob Goodwin, M. Bajzíková, Jaromíra Kovářová, M. Peterka, B. Yan and 15 more. Cell Metabolism, 2015

722 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4483b411afe45123c903d3620b445e8cc04ec375

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Citations in the corpus

Mitochondrial metabolism and cancer (2017, background): “In line with this notion, the ability of mtDNA-depleted (ρ) cells to form tumors upon inoculation in immunocompatible hosts is compromised [60-62], but can be recovered (at least in some settings) upon horizontal transfer of whole mitochondria from the host [60, 63].”
Metabolic Interactions in the Tumor Microenvironment (2017, background): “In a similar study employing two murine ρ0 cancer cell lines, the mitochondriadeficient cancer cell lines form tumors with an increased latency [98].”
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “This requirement for mtDNA appears so stringent that, in one study, injected r cells formed tumors only after acquiring mtDNA from the host (Tan et al., 2015).”
Targeting Metabolism for Cancer Therapy (2017, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript ability to do respiration, providing compelling evidence that respiration is required and selected for in tumorigenesis (Tan et al., 2015a).”
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer (2016, background): “However, recent work suggests that there is selective pressure to maintain functional mitochondria in tumors (Tan et al., 2015).”
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer (2017, background): “exosomes | mitochondrial DNA | cancer stem cells | hormonal therapy | metastasis E vesicles (EVs) are mediators of juxtacrine and paracrine signaling required for metastatic progression (1, 2).”
Autophagy, Metabolism, and Cancer (2015, neutral): “Depletion of mitochondrial DNA also diminishes tumorigenesis and metastasis (77).”
Mitochondrial DNA in inflammation and immunity (2020, positive): “Horizontal transfer of mitochondria from cells in the tumour microenvironment restored respiration in q 0 cells and instigated tumour growth [197].”