Astrocyte glycogen and brain energy metabolism

By Angus M. Brown, B. Ransom. Glia, 2007

624 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/7486e173a06fb8473d7bbe1856b2105726c35d1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. Igor Allaman
3. Pierre J. Magistretti
4. H. Vinters
5. C. Zhong
6. M. Bélanger
7. Zhichun Chen
8. J. Burda

In Developmental Neuroscience

1. M. Sofroniew
2. H. Vinters
3. Pierre J. Magistretti
4. Igor Allaman
5. J. Burda
6. M. Pekny
7. M. Pekna

In Physiology

1. Igor Allaman
2. Pierre J. Magistretti
3. H. Vinters
4. Joseph A. Fisher
5. Philip N. Ainslie
6. Y. Tzeng
7. C. Willie
8. C. Zhong

Citations in the corpus

• Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “It has been demonstrated that glycogen could be used to provide lactate for neuronal metabolism during hypoglycemia (Brown and Ransom, 2007; Pellerin et al., 2007), which may suggest astrocytes play critical roles in both normal glucose supply and hypoglycemic conditions.”
• Astrocytes: biology and pathology (2009, background): “Although it was known for many years that astrocytes are the principal storage sites of glycogen granules in the CNS and that the greatest accumulation of astrocytic glycogen occurs in areas of high synaptic density [183, 184], the functional contribution of these stores was originally discounted [2”
• The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “A steady glucose supply is necessary since the central nervous system (CNS) is able to store only a limited amount of glycogen within astrocytes (Brown & Ransom, 2007), glial cells outnumbering neurons in the human brain.”
• Integrative regulation of human brain blood flow (2014, background): “Due to limited capacity for substrate storage (Brown & Ransom, 2007) and the high metabolic rate of brain tissue, the precise regulation of cerebral blood flow (CBF) is critical for maintenance of constant nutrient and oxygen supply to the brain.”
• Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “…that increasing astrocytic glycogen stores preserves neuronal function and viability in conditions of limited energy availability, such as hypoglycemia, provided additional evidence for neuron-glia metabolic coupling involving glycogen (Brown and Ransom, 2007; Brown, 2004; and references therein).”