Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans
By A. Meléndez, Z. Tallóczy, M. Seaman, E. Eskelinen, David H. Hall, Beth Levine. Science, 2003
1,354 citations recorded by the source corpus.
Subfields: Aging
View Paper: https://www.semanticscholar.org/paper/9b056c36923a91a6129899df8d5db1ae1f9f15d3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
- David M. Sabatini
- C. Kenyon
- N. Mizushima
- D. Klionsky
- Guido Kroemer
- Linda Partridge
- T. Blackwell
- M. Hansen
Citations in the corpus
- Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “These reporters can be expressed either in specific cells and tissues or throughout the animal.(189,593,787,788) LGG2 is the second LC3 homolog and is also a convenient marker for autophagy either fused to GFP,(789) especially when expressed from an integrated transgene to prevent its germline silen”
- Role for Rab7 in maturation of late autophagic vacuoles (2004, background): “Recent results have shown that autophagy also contributes to cell homeostasis in muscle, liver and pancreas (Eskelinen et al., 2003; Tanaka et al., 2000), as well as to development, growth regulation, cancer and longevity (Liang et al., 1999; Melendez et al., 2003).”
- With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, positive): “The role of autophagy in modulating life span was first identified when the extended life span of the C.elegans mutant in daf-2, which encodes an insulin-like receptor, was significantly abrogated by inhibition of the autophagy gene bec-1 (Melendez et al., 2003).”
- The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span (2004, background): “In C. elegans, these include mutants in the daf-2 insulin receptor (Kimura et al., 1997) and age-1PI3 kinase (Morris et al., 1996).”
- Autophagy and aging. (2011, background): “(Insulin/IGF-1 receptor) loss-of-function mutant in C. elegans Enhanced autophagy and life span Abolishment of longevity phenotype in animals with loss-of-function mutations of bec-1 or upon atg-7 or atg-12 RNAi Melendez et al., 2003 Dietary restriction mutant eat-2 (ad1113) in C. elegans.”