The Toll receptor family and microbial recognition.

By R. Medzhitov, CharleS. Jr Janeway. Trends in Microbiology, 2000

742 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9aa009b2d03046330d189297efed5239ac7359b2

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Citations in the corpus

The fetal inflammatory response syndrome. (2007, background): “The first PRRs identified where Toll-like receptors (TLRs)(33,34) and the ligands for these receptors were originally thought to be of microbial origin (eg, endotoxin, peptidoglicans, viral RNA, etc).(13,33,34) It is now known that TLRs can recognize not only microbial products but also host signals”
Para-inflammation in the aging retina. (2009, background): “PAMPs are produced only by the invading microbes and are not expressed in eukaryotic cells, and this difference underpins the mechanism which allows the innate immunity to discriminate between ‘‘infectious non-self’’ and ‘‘non-infectious self’’ (Medzhitov and Janeway, 2000a,b,c).”
Salmonella interactions with host cells: type III secretion at work. (2001, background): “Indeed, like any other bacteria, Salmonella encodes several molecules (e.g., lipopolysaccharide, lipoproteins, flagella, etc) collectively recognized as pathogen-associated molecular patterns (PAMPs) that are capable of stimulating the innate immune system (Medzhitov & Janeway 2000a,b).”
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection (2003, background): “APC-free reconstitution of NKT cell activation Because LPS is a known agonist for Toll-like receptor 4 (ref”
Mammalian glycosylation in immunity (2008, neutral): “Mammals have developed a phyloglycomic recognition system, which includes a subset of Toll-like receptors (TLRs) and C-type lectins, to detect the glycans of lower organisms as a means of non-self discrimination and immunological activatio”
Cancer vaccines: between the idea and the reality (2003, background): “Our understanding of the specific characteristics and behaviour of cells of the immune system at mucosal surfaces is still not complete, but information is beginning to emerge with regard to the migration of lymphocytes and APCs to those sites and the induction of immunity versus toleranc”
The Role of Inflammation and Infection in Preterm Birth (2007, background): “).(15,35,36) It is now known that Toll-like receptors can recognize not only microbial products but also host signals produced in the context of injury, such as heat-shock proteins.”
The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS (2002, background): “…Because the receptors CD14 and TLR4 are required for the molecular and cellular effects of LPS in circulating monocytes (Means et al., 2000, 2001; Medzhitov and Janeway, 2000; Zhang and Ghosh, 2001), we next determined whether these receptors are expressed in CNS microglia or other glial cells.”
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “crobial genes and inflammatory cytokines (2, 23, 29).”