Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

By R. Steinman, Michel C. Nussenzweig. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,268 citations recorded by the source corpus.

Subfields: Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. (2006, background): “Indeed, many of the discussions of antigen transfer between migratory and lymphoidresident DC populations have been couched in terms of steady-state presentation and T cell tolerance (Inaba et al., 1998; Steinman and Nussenzweig, 2002).”
Lentivirus-delivered stable gene silencing by RNAi in primary cells. (2003, background): “DC also play a critical role in maintenance of toler- ance (Steinman and Nussenzweig 2002).”
HMGB1 is an endogenous immune adjuvant released by necrotic cells (2004, background): “HMGB1 is an endogenous immune adjuvant released by necrotic cells”
Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “As both directly and indirectly activated DCs have similar potential to interact with naive T cells (46), the consequence of this number disparity is that a self-reactive non-tolerant T cell would be more likely to encounter its cognate antigen on an indirectly activated DC than on a directly activa”
Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State (2003, background): “In permanence, tissue self-Ag, originated from dying cells, molecule shedding, or direct capture from live cells, are presented by Ag-presenting cells in draining LNs (51, 52).”