Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
By G. V. Michailov, M. Sereda, Bastian G Brinkmann, Tobias M. Fischer, B. Haug, C. Birchmeier, Lorna W. Role, Cary Lai, Markus H. Schwab, K. Nave. Science, 2004
957 citations recorded by the source corpus.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Immunology
View Paper: https://www.semanticscholar.org/paper/9a6345d99b5d2a7e8a7e2fe3fc45c5b92e834428
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Citations in the corpus
- Axon-glial signaling and the glial support of axon function. (2008, background): “F or p er so na l u se o nl y. and in transgenic mice that overexpress NRG1 type III [in dorsal root ganglia (DRG) and motoneurons], peripheral myelin is thicker than normal (Michailov et al. 2004).”
- LINGO-1 negatively regulates myelination by oligodendrocytes (2005, background): “Several different receptor-ligand pairs are important for oligodendrocyte differentiation and/or myelination, including ErbB2 and neureguli”
- Remyelination in the CNS: from biology to therapy (2008, background): “How is the relationship between myelin parameters and axon size established in myelination, and why is it disengaged in remyelination? In the PNS, axonally expressed neuregulin 1 ( NRG1 ) type III has a pivotal role: reduced expression of type III NRG1 leads to a thinner than normal myelin sheath (i”
- Bace1 modulates myelination in the central and peripheral nervous system (2006, background): “The g -ratio is a standard ultrastructural readout that provides a reliable index of myelination independent of axonal diamete”