LINGO-1 negatively regulates myelination by oligodendrocytes

By S. Mi, Robert H Miller, X. Lee, M. Scott, Svetlane Shulag-Morskaya, Z. Shao, Jufang Chang, G. Thill, M. Lévesque, Mingdi Zhang and 7 more. Nature Neuroscience, 2005

629 citations recorded by the source corpus.

Subfields: Cell Biology, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/65861f205f61b03c23e36353105698b02f8dbf0a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Oligodendrocytes: biology and pathology (2009, background): “Loss of LINGO-1 function in oligodendrocytes leads to increased myelination, whereas its overexpression inhibits myelin formation [122].”
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “Several such differentiation inhibitors have been suggested to have roles including the Notch pathway (John et al. 2002), PSA-NCAM (Charles et al. 2002), hyaluronan (Back et al. 2005), and LINGO-1 (Mi et al. 2005).”
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. (2008, background): “In recent studies, it has been shown that factors such as Lingo-1 and PSA-NCAM have the capability to prevent remyelination (Charles et al., 2000, 2002; Mi et al., 2005).”
White matter in learning, cognition and psychiatric disorders. (2008, positive): “Axon‐glial signaling through these receptors also regulates oligodendrocyte differentiation and myelination, as shown by disrupting LINGO-1, a protein that interacts with the Nogo receptor to inhibit myelination [ 77 ].”
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation (2006, background): “However, especially relevant in this regard is the recent report that activation of LINGO inhibits O4 immature oligodendrocytes from maturing into differentiated oligodendrocytes, by promoting the activity of RhoA GTPase while suppressing that of Fyn tyrosine kinase (Mi et al., 2005).”
Remyelination in the CNS: from biology to therapy (2008, background): “It will be useful to determine whether the highly encouraging effects of antibodies to LINGO1, a negative regulator of OPC differentiation in developmen”