Protection and Damage from Acute and Chronic Stress: Allostasis and Allostatic Overload and Relevance to the Pathophysiology of Psychiatric Disorders

By Bruce S. McEwen. Annals of the New York Academy of Sciences, 2004

1,623 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/9a4c07593181e2bde15bd55dee748a1b6b29b042

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Biological Psychiatry

In Social Psychology

Citations in the corpus

Stress, eating and the reward system. (2007, background): “Life is stressful! Daily life demands constant re-establishment and maintenance of a dynamic equilibrium in the face of a fast changing environment, also called ‘allostasis’ [1].”
Prolonged institutional rearing is associated with atypically larger amygdala volume and difficulties in emotion regulation (2010, positive): “Impact of adversity on limbic regions Stressful experiences produce specific changes in the brain, particularly in limbic regions like the amygdala and hippocampus (McEwen, 2004).”
The development of coping. (2007, background): “Over time, stress-inducing interactions with caregivers can have a negative effect on the normative development of both neurological and emotional functioning (Cicchetti & Rogosch, 2009; Herbert et al., 2006; McEwen, 1998; 2004; Sapolsky, 1999).”
Continuous inference of psychological stress from sensory measurements collected in the natural environment (2011, background): “cessive, chronic, and repeated exposures to stress can lead to significant negative health consequences [38, 29].”
The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007, background): ““Think-ing,” or higher-order cognitive functioning, is dependent to a great extent on the integrity of the PFC. Extensive research and recent imaging studies have shown that the PFC is critically involved in guiding behavior during divided attention (Nebel et al. [364]; Dannhauser et al. [365]) and ”
Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS) (2008, background): “Both DHEAS and cortisol are considered in the calculation of allostatic load, which is a measure of the cumulative physiological burden to the body of accommodating multiple stressors over time [194].”
Is burnout a depressive disorder? A reexamination with special focus on atypical depression. (2014, background): “…al., 2001), the two syndromes, from a clinical standpoint, tend to overlap at both an etiological level—with unresolvable stress as the nodal contributory factor—(Hätinen, Kinnunen, Pekkonen, & Kalimo, 2007; McEwen, 2004; Rydmark et al., 2006) and a symptom level (Bianchi et al., 2013; Kahn, 2008).”
Weighing the Costs of Disaster (2010, background): “For example, high allostatic load has been linked to impaired immunity, atherosclerosis, obesity, bone decay, and atrophy of brain cells (Kiecolt-Glaser, Glaser, Gravenstein, Malarkey, & Sheridan, 1996; Magariňos, Verdugo, & McEwan, 1997; McEwen, 2004).”
Psychobiological Responses to Social Self Threat: Functional or Detrimental? (2009, background): “This is not without consequence, as repeated or chronic elicitation of these inflammatory and hormonal responses can lead to dysregulation of important biological systems and a range of negative mental and physical health outcomes (e.g., diabetes, cardiovascular disease, depression; McEwen, 2004).”
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress (2007, background): “…changes in humans and rodents, manifested as depressive-like symptoms, a hyperanxious state, and learning/ memory deficits (Mizoguchi et al., 2000; McEwen, 2004), paralleled by structural damage (Sousa and Almeida, 2002) and impaired synaptic plasticity (Sousa et al., 1998; Kim and Diamond,…”
Let’s Focus on Solutions to Entrepreneurial Ill-Being! Recovery Interventions to Enhance Entrepreneurial Well-Being (2021, background): “longitudinal buildup of allostatic load that endangers entrepreneurs’ physical and mental health (McEwen, 2004).”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, neutral): “The HPA axis represents the major neuroendocrine stress response system that serves to adapt the organism to change in demand and thereby maintains stability and health (McEwen, 2004).”