Flavonoids: antioxidants or signalling molecules?
By Robert J. Williams, J. Spencer, C. Rice-evans. Free Radical Biology & Medicine, 2004
1,986 citations recorded by the source corpus.
Subfields: Biochemistry, Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/9a14b40639cf9e345f4390cf1c20e0f91ca2072f
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Citations in the corpus
- Proximate and Phytochemical Composition of Moringa oleifera Leaves at Three Stages of Maturation (2011, background): “They also induce mechanisms that may kill cancer cells and inhibit tumor invasion (Williams et al., 2004).”
- Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. (2005, background): “On the other hand, accumulating evidence indicates that polyphenols exhibit several additional properties in complex biological systems, but which are as yet poorly understood [45–47].”
- Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “However, another important characteristic of flavonoids is their ability to modulate cell signaling pathways (Williams et al. 2004; Higdon et al. 2023d).”
- Flavonoids: new roles for old molecules. (2010, background): “…have anti-oxidant, anti-proliferative, antitumor, anti-inflammatory, and pro-apoptotic activities, and some molecular targets have been identified (Williams et al. 2004; Taylor and Grotewold 2005; Garcia-Mediavilla et al. 2007; Pandey et al. 2007; Sung et al. 2007; Kim et al. 2008; Singh et al.…”
- Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “Understanding whether and how luteolin's redox regulation activity is involved in its cellular effects is key to evaluating its potential as an anticancer agent, a cardioprotectant, or an inhibitor of neurodegeneration [34].”
- Apigenin: A Promising Molecule for Cancer Prevention (2010, positive): “Several studies have demonstrated that apigenin exerts a broad range of molecular signaling effects (42).”
- The role of root exudates in rhizosphere interactions with plants and other organisms. (2006, background): “Thus, flavanoids are well characterized in animal cells as being signaling molecules (188), and in plants they act in many signaling and regulatory pathways.”
- Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action (2010, background): “mediated via their interactions with neuronal and glial signaling pathways that affect gene expression and interfere with the cell death mechanisms [233,234].”
- Multiple functional roles of anthocyanins in plant-environment interactions. (2015, background): “8-glutathionyl quercitin reported in Williams et al. (2004) (1); 1-glutathionyl cyanidin-3 glucoside hypothesized on the similarity with 20-glutathionyl quercetin conjugate as r”