Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.

By H. Maeda. Journal of Controlled Release, 2012

763 citations recorded by the source corpus.

Subfields: Education

View Paper: https://www.semanticscholar.org/paper/999f20b7be371e1712c4bf1a84fdd831f2f8ece5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Education

1. Peter L. Choyke
2. M. Hope
3. Hisataka Kobayashi
4. P. Cullis
5. S. Mitragotri
6. A. Anselmo

Citations in the corpus

• Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target? (2013, background): “There are several other approaches to targeting the vasculature or stroma to promote vascular supply and vascular permeability in tumors, such as hyperthermia (65, 66), radiotherapy (67), high intensity focused ultrasound (68) and various mediators including bradykinin (52-55), nitric oxide-releasin”
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Such problems were encountered by SMANCS, a treatment mainly intended for hepatocellular carcinoma [70], and by others [305] for which the interest dwindled as clinical hurdles were exposed.”
• Nanoparticles in the clinic (2016, background): “, tumors via EPR effect).(39,110,111) Similar effects can be achieved using hydrophilic sugar (e.”
• Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, neutral): “the endothelial cadherin-mediated intercellular connections [74].”
• Challenges and key considerations of the enhanced permeability and retention (EPR) effect for nanomedicine drug delivery in oncology (2013, neutral): “Prostaglandins COX-1 Beraprost sodium: PGI2 agonist works via vascular dilatation and extravasation (5).”
• Lipid Nanoparticle Systems for Enabling Gene Therapies. (2017, background): “The preferential accumulation of small LNP into tumor tissue has been termed the “enhanced penetration and retention” (EPR) effect.(8) The EPR effect, in combination with LUVs with long circulation lifetimes, can improve tumor delivery by 10-fold or more compared to equivalent doses of free drug and”