Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

By M. Brand, Telma C Esteves. Cell Metabolism, 2005

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Mitochondria in innate immune responses (2011, background): “Mild uncoupling decreases mROS generation and, as such, the reduced MAVS signalling and RLR-dependent antiviral responses induced by uncoupling may be due in part to lowered mROS generatio”
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “mitochondrial production of ROS (52, 53) acting to pro-”
Mechanisms of sepsis-induced cardiac dysfunction (2007, background): “Increased expression of mitochondrial uncoupling proteins (UCP) could reduce mitochondrial membrane potential and ATP synthesis (85, 86).”
Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation (2015, background): “UCP2 belongs to a family of mitochondrial UCPs comprising UCP1, 2, and 3, all three with proton leak activity (48,49).”
Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “Regardless of the wealth of information gained in these studies, there remains a great ambiguity about the precise role of these UCPs in cellular functions (Brand and Esteves, 2005).”