The computational role of dopamine D1 receptors in working memory

By Daniel Durstewitz, Jeremy K. Seamans. Neural Networks, 2002

297 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9984c16deb2ec18ac9737923648b7e7dafd1c89e

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In Cellular and Molecular Neuroscience

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Citations in the corpus

The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “Thus, the overall network system will tend to remain in a particular state unless it receives substantial additional inputs (Durstewitz and Seamans, 2002).”
Dopamine and Cognitive Control in Prefrontal Cortex. (2019, background): “In this framework, PFC networks are either in a D1R-dominated state, in which an increase in recurrent excitation by increasing excitatory NMDA currents and a decrease in spontaneous activity by increasing inhibitory GABA currents stabilizes representations in working memory [142,144] (Figure 8C).”
Modafinil: A Review of Neurochemical Actions and Effects on Cognition (2008, background): “This includes a depression of background PFC activity, which serves to make the self-sustained activity robust to noise (eg, distractors) (Durstewitz and Seamans, 2002).”
Metalearning and neuromodulation (2002, background): “It has also been shown that stable working memory requires activation dopamine D1 receptor (Sawaguchi & Goldman-Rakic, 1994; Durstewitz & Seamans, 2002).”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “In computer simulations of realistic PFC circuits, if the network is quiescent, simulated D1 receptor stimulation exerts neglible effects on spontaneous firing relative to the large enhancement in evoked ‘‘delay-period’’ persistent firing (Durstewitz et al., 2000a; Durstewitz and Seamans, 2002).”
Computational models of schizophrenia and dopamine modulation in the prefrontal cortex (2008, background): “Thus, the stability of the attractor state is reduced, resulting in difficulty in maintaining a short-term memory and, consequently, in difficulty in maintaining attention 66,77 (FIG.”
Design for a working memory. (2009, background): “This class of tasks is interesting because they focus on a fundamental dilemma of WM, to strike the balance between holding on to representations and replacing them by new ones (Dreisbach & Goschke, 2004; Durstewitz & Seamans, 2002).”