Dopamine and Cognitive Control in Prefrontal Cortex.

By Torben Ott, Andreas Nieder. 2019

425 citations recorded by the source corpus.

Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on the prefrontal cortex. These cognitive functions are heavily influenced by the neuromodulator dopamine. We review here recent insights exploring the influence of dopamine on neuronal response properties in prefrontal cortex (PFC) during ongoing behaviors in primates. This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands. For each of these roles, we propose a neuronal microcircuit based on known mechanisms of action of dopamine in PFC, which are corroborated by computational network models. This conceptual approach accounts for the various roles of dopamine in prefrontal executive functioning.

Subfields: Cognitive Neuroscience, Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Naomi P. Friedman
2. Trevor W. Robbins
3. Liyuan Wang
4. Jun Zhu
5. Hang Su
6. Eun-Young Lee
7. Xingxing Zhang
8. R. Engle

In Neuroscience

1. Liyuan Wang
2. Jun Zhu
3. Trevor W. Robbins
4. Hang Su
5. Naomi P. Friedman
6. Eun-Young Lee
7. Xingxing Zhang

Citations in the corpus

• A Comprehensive Survey of Continual Learning: Theory, Method and Application (2023, background): “, a neocortex region) regulating sensory information from various cortical modules [122], [319], [411] and the mushroom body (i.”
• The role of prefrontal cortex in cognitive control and executive function (2021, background): “For example, dopamine receptors in the PFC have been related hypothetically to three main elements of CC: gating; maintaining and relaying motor commands; and producing error learning signals [116, 124, 125].”
• Memory Deficits in Parkinson’s Disease Are Associated with Impaired Attentional Filtering and Memory Consolidation Processes (2023, result): “The current result is in line with previous findings reporting a critical role of the frontostriatal pathway in controlling the access of incoming information into memory systems [20,61,62].”