Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.

By D. Schmucker, James C. Clemens, Huidy Shu, C. Worby, Jian Xiao, M. Muda, J. Dixon, S. Zipursky. Cell, 2000

1,125 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/9957cff18fd737429d9c29abdbb7e220079e22b7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Tessier-Lavigne
2. L. Jan
3. Y. Jan
4. J. Chilton

In Cellular and Molecular Neuroscience

1. M. Tessier-Lavigne
2. J. Chilton
3. L. Jan
4. Y. Jan
5. Daniel H. Geschwind
6. N. Šestan

Citations in the corpus

• Listening to silence and understanding nonsense: exonic mutations that affect splicing (2002, background): “cgi?l=35652"> Dscam ), can be processed to generate potentially 38,016 different mature transcript”
• Circular RNA Expression: Its Potential Regulation and Function (2016, background): “Dramatic examples of the potential diversity that can be generated from a single gene through this process are highlighted in the nervous systems of flies, where the Dscam gene can give rise to >20 000 different proteins, whose diversity is functionally essential [41].”
• Mechanisms and molecules of neuronal wiring: a primer. (2011, background): “Through alternative splicing, over 19,000 isoforms of DsCAM can be generated (Schmucker et al. 2000).”
• Molecular mechanisms of axon guidance. (2006, background): “In fact, 38,000 isoforms can theoretically be generated (Schmucker et al., 2000).”
• Branching out: mechanisms of dendritic arborization (2010, background): “Extensive alternative splicing can potentially generate over 38,000 isoform”
• Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly. (2009, neutral): “[34].”
• Alternative splicing: new insights from global analyses. (2006, background): “Remarkably, this gene, which functions in both axon guidance and immune defense (Schmucker et al., 2000; Watson et al., 2005; Chen et al., 2006), has the potential to encode over 38,000 different splice variants, primarily via tandem arrays of mutually exclusive alternative exons, many of which over”
• Alternative splicing and evolution: diversification, exon definition and function (2010, background): “The multiple, mutually exclusive exons of Dscam lead to enormous numbers of splice variant”
• The sea urchin immune system (2006, background): “Drosophila has eight Toll genes and humans have eleven, however, plant genomes have hundreds of R genes which have LRRs. Similar to the plant system, the purple sea urchin has a very large array of predicted Toll genes (Pancer and Cooper, 2006).”
• Genome-wide detection of alternative splicing in expressed sequences of human genes (2001, background): “In the Drosophila gene Dscam, combinatorial alternative splicing of ‘cassettes’ of exons reminiscent of the combinatorial generation of immunoglobulin diversity, produces thousands of distinct functional isoforms (4).”