The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

By D. Smart, M. Gunthorpe, J. Jerman, S. Nasir, J. Gray, A. Muir, J. Chambers, A. Randall, J. Davis. British Journal of Pharmacology, 2000

783 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Pharmacology

View Paper: https://www.semanticscholar.org/paper/98f75f0ada652e4205a7223f6cbd26859e5a4624

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Julius
2. R. Ross
3. M. Caterina
4. S. Jordt
5. D. Bautista
6. P. Castillo
7. Y. Hashimotodani
8. R. Mechoulam

In Endocrine and Autonomic Systems

1. V. Di Marzo
2. R. Pertwee

In Pharmacology

1. P. Castillo
2. Y. Hashimotodani
3. V. Di Marzo
4. D. Julius
5. R. Ross
6. R. Mechoulam
7. R. Pertwee

Citations in the corpus

• Endocannabinoid signaling and synaptic function (2012, background): “Of note, AEA is a partial agonist at the CB 1 R but a full agonist at TRPV1 channels (Smart et al., 2000; Zygmunt et al., 1999).”
• Induction of vanilloid receptor channel activity by protein kinase C (2000, background): “Anandamide can directly gate VRs and this action is implicated in the regulation of vascular ton”
• Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 (2004, background): “Our current findings also extend the concept that some TRP channels may serve as ionotropic cannabinoid receptors, which, in the context of the primary afferent nerve fibre, may contribute to inflammatory hypersensitivity or vasodilatio”
• Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide (2001, methodology): “Response calibration was carried out by measuring the ¯uorescence intensity of intracellular ¯uo-3 with known extracellular [Ca2+] (Molecular Probes).”
• TRPV3 is a temperature-sensitive vanilloid receptor-like protein (2002, methodology): “Calcium imaging Changes in intracellular calcium were monitored using a fluorometric imaging plate reader (FLIPR) platform as previously describe”
• Anandamide and vanilloid TRPV1 receptors (2003, background): “…Sprague et al. (2001) o4 (501C) 120 Sprague et al. (2001) HEK 293 (human) [Ca2+]i (FLIPR) 7.4 5.9470.06 100 Smart et al. (2000) 6.4 5.7670.04 100 Smart et al. (2000) 7.4 5.6070.10 100 Ralevic et al. (2001) 7.4 6.66 (with LEA)b F Smart et al. (2000) 7.4 5.74 (no LEA) F Smart et al. (2002) F…”
• The vanilloid receptor: a molecular gateway to the pain pathway. (2001, background): “In fact, a high-throughput screen of>1000 bioactive substances reidentified anandamide as an activator of VR1 (Smart et al 2000), and a directed analysis of arachidonic acid metabolites identified lipooxygenase products [e.g. 12- or 15-(S)-Hydroperoxyeicosa-5Z, 8Z, 11Z, 13E-tetraenoic acid] as…”