The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.

By Li Yuan, Jian-Guo Liu, Jian Zhao, E. Brundell, B. Daneholt, C. Höög. Molecules and Cells, 2000

697 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/98e0a662a5fe1f61b04ab56e185bbf31b58ed1f3

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Citations in the corpus

Specific arrests of spermatogenesis in genetically modified and mutant mice (2004, background): “In case of Sycp3 deficiency, the synaptonemal complex is not formed and postmeiotic stages are absent (Yuan et al., 2000).”
To err (meiotically) is human: the genesis of human aneuploidy (2001, background): “Other possible approaches that make use of animal models include analysis of recombination and non-disjunction in appropriate knockout mice: several such meiotic mutants have now been generated and, in those in which the female is fertile (for example, Ref”
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. (2001, background): “In these regions, sister chromatids associate with one another in the presence of certain axial element proteins, BRCA1, BRCA2, Rad51, ATR, and other DNA replication/repair/checkpoint proteins (Keegan et al., 1996; Scully et al., 1997b; Chen et al., 1998; Yuan et al., 2000).”
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis (2004, background): “Disruption of the other genes that are involved in homologous chromosome synapsis formation, such as Dmc1, Sycp3, Spo11and Atm, leads to failed synapsis formation and causes meiotic cell death (Romanienko and Camerini-Otero, 2000; Scherthan et al., 2000; Yoshida et al., 1998; Yuan et al., 2000).”
Corrigendum: Germline stem cells and follicular renewal in the postnatal mammalian ovary (2004, background): “Thus, expression of synaptonemal complex protein 3 (SCP3), a meiosis-specific protein needed for formation of axial lateral elements of the synaptonemal comple”