To err (meiotically) is human: the genesis of human aneuploidy

By T. Hassold, P. Hunt. Nature reviews genetics, 2001

2,416 citations recorded by the source corpus.

Subfields: Genetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/30cdf6d0f40992be8cc7dec9c776852b22d47ac1

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In Genetics

In Pediatrics, Perinatology and Child Health

Citations in the corpus

RNAi-mediated chromatin silencing in fission yeast. (2008, background): “Chromosome loss or gain as a consequence aberrant centromere function can drive aneuploidy and tumour formation and ultimately lead to a reduction in organism viability (Hassold and Hunt 2001; Wassmann and Benezra 2001).”
Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population (2004, background): “Aneuploidy (an error in cell division) during meiosis is thought to be the most common known cause of mental retardation as well as being the leading genetic cause of pregnancy loss in humans (Hassold and Hunt 2001).”
Meiotic Recombination: The Essence of Heredity. (2015, background): “Although aging clearly impacts oocyte chromosome segregation via multiple pathways (Hassold and Hunt 2001; Selesniemi et al. 2011; Nagaoka et al. 2012), a number of studies indicate that progressive weakening of sister-chromatid cohesion is likely to be a major mechanism (Wolstenholme and Angell…”
Epigenetic regulation of centromeric chromatin: old dogs, new tricks? (2008, background): “The region responsible for this difference is in the first loop (L1) and second alpha helix (2), which corresponds to CENP-A residues that are involved in centromere recruitment (see below) (Fig.”
The origin of human aneuploidy: where we have been, where we are going. (2007, background): “Based on these analyses, three general ‘rules’ of human non-disjunction emerged: first, regardless of the specific chromosome, most trisomies originate during oogenesis; second, for most chromosomes, maternal meiosis I (MI) errors are more common than maternal meiosis II (MII) errors; and third, the”
Target highlights in CASP13: experimental target structures through the eyes of their authors (2019, background): “essential for reproduction, genetic diversity, and evolution, with errors in meiosis leading to human infertility, miscarriage and germ cell cancers.(20) At the center of this process is the establishment of homologous chromosomes pairs through their physical tethering by the synaptonemal complex, a”
Integrative structure modeling with the Integrative Modeling Platform (2017, background): “73–76 The spindle pole body (SPB) of Saccharomyces cerevisiae is a simple model of the centrosome.”