DNA topoisomerases: structure, function, and mechanism.

By James J. Champoux. Annual Review of Biochemistry, 2001

2,641 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage (2005, background): “BLM functions in association with topoisomerase III (Top3 ) (68), a type I class of topoisomerases (11, 37, 67, 69).”
Topoisomerase I inhibitors: camptothecins and beyond (2006, neutral): “and two genes that encode TOP3α and TOP3β (reviewed in Ref”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “These enzymes are not capable of increasing the degree of supercoiling (Champoux, 2001).”
Cellular roles of DNA topoisomerases: a molecular perspective (2002, background): “The purpose of this review is to provide a perspective of the cellular roles of these remarkable enzymes from a vista of their basic reaction characteristics — a more comprehensive coverage of the literature can be found in several recent review”
DNA topoisomerase II and its growing repertoire of biological functions (2009, neutral): “There are two classes of topoisomerases: type I enzymes, which introduce single strand breaks in DNA, and type II topoisomerases, which introduce double strand break”