Topoisomerase I inhibitors: camptothecins and beyond

By Yves Pommier. Nature Reviews. Cancer, 2006

2,121 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6519b6080980ec0ad8e2d6ff7f17f8d57d651186

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1 (2016, background): “Topoisomerase I inhibitors such as irinotecan (CPT-11) bind to topoisomerase I-DNA cleavable complexes and stabilize them, resulting in the induction of double-strand DNA breaks and apoptosis (15).”
Microsatellite instability in colorectal cancer—the stable evidence (2010, background): “If this dysfunction is unresolved by the DNA repair system, it eventually leads to apoptosis and cell death”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “(A) Line drawings of the chemical structures of common chemotherapeutic agents and (B) their Log P values and indications, including Cisplatin, Doxorubicin, Paclitaxel, Cytarabine, Vincristine, Docetaxel, Camptothecin, Topotecan, Vinorelbine, Irinotecan, Oxaplatin, Daunorubicin, and Rapamycin (Bolwe”
Natural compounds for cancer treatment and prevention. (2009, background): “The hydroxyl group and S-conformation of the chiral centre to which it is attached are absolute requirements for biological activity (the hydroxyl group is essential for cytotoxicity, the lactone ring for topoisomerase I targeting activity) [72,73].”
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs (2010, positive): “Four lines of evidence demonstrate the selective poisoning of Top1 by CPT (reviewed in Pommier, 2006, 2009): (1) only the natural CPT isomer is active against Top1 (Hsiang et al., 1989; Jaxel et al., 1989); (2) genetically modiﬁed yeast deleted for TOP1 ( Top1 D ) is immune to CPT (Eng et al.,…”
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics (2022, background): “Its active lactone can intercalate between DNA bases in the topoisomerase-I cleavage complex.(129) The coupling site of topotecan in the cleavage complex interferes with the topoisomerase-I while reiterating the scratched DNA strand in the wake of releasing the strain.”