Regulation and function of NF-kappaB transcription factors in the immune system.

By Sivakumar Vallabhapurapu, M. Karin. Annual Review of Immunology, 2009

2,752 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/97d401da0bd370b2ab88720c2683997566c668dc

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Citations in the corpus

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “In some cells, NF-kB and STAT3 are critical for cell survival, for instance NF-kB in developing B cells or thymocytes [16], and STAT3 in activated T cells, subjected to activation-induced cell death [5].”
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study (2020, background): “It is well established that RelA and p50 heterodimers are responsible for transcription of target genes when the canonical NF-κB pathway is activated, while RelB and p52 form a heterodimer in non-canonical NF-κB pathway.(3,27) In the steady-state settings, RelA and p50 are sequestered in the cytopla”
The outs and the ins of sphingosine-1-phosphate in immunity (2011, neutral): “Much has been learnt about the complex signalling pathways downstream of TLR”
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “The NF-κB proteins are normally sequestered in the cytoplasm by a family of inhibitors, including IκBα and other ankyrin repeat-containing proteins [6,12].”
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis (2014, neutral): “Mice homozygous for IKKb (IKKb), both SOD1 and WT, displayed serious immune dysfunction, such as enlarged spleens, eye infections, and missing or very brittle teeth, which have been previously reported in mice with myeloid cells devoid of NF-kB (Ruocco et al., 2005; Vallabhapurapu and Karin, 2009).”
Signaling via the NFκB system (2016, background): “p105 is endoproteolytically cleaved into a mature protein, p50, that is able to dimerize with other NFκB proteins (predominantly RelA).(2) p105 processing is generally a constitutive process that occurs in unstimulated cells.”