Molecular Evolution of Human Coronavirus Genomes
By Diego Forni, Rachele Cagliani, Mario Clerici, Manuela Sironi. Trends in Microbiology, 2016
711 citations recorded by the source corpus.
Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. Video Abstract
Subfields: Animal Science and Zoology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/d5bd54ba0dce8221986d1ed55686350d89492f27
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Animal Science and Zoology
In Infectious Diseases
- Philippe Lemey
- Ahmed Sobieh
- Maciej F. Boni
- Andrew Rambaut
- Yosra A. Helmy
- M. Fawzy
- Scott P. Kenney
- A. Shehata
Citations in the corpus
- The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control (2020, background): “Coronaviruses have repeatedly evolved during the past 1000 years [17].”
- Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China (2020, neutral): “Coronavirus, which usually causes respiratory tract infections in humans, has been linked to several infectious diseases and subsequent global challenges [1,2].”
- The human coronavirus HCoV-229E S-protein structure and receptor binding (2019, background): “They 39 share a common ancestor thought to have originated in bats (3) and several genera that use a 40 wide range of protein and carbohydrate receptors have evolved (4, 5).”
- COVID-19: The first documented coronavirus pandemic in history (2020, neutral): “[27] Forni D, Cagliani R, Clerici M, Sironi M.”
- Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic (2020, background): “Unlike other viruses that have emerged in the past two decades, coronaviruses are highly recombinogenic (Forni et al., 2017; Hon et al., 2008; Lam et al., 2018).”