Mitochondria, oxygen free radicals, disease and ageing.

By S. Raha, B. Robinson. TIBS -Trends in Biochemical Sciences. Regular ed, 2000

1,108 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/9789b39b1e5f28c7c7d36aaea2df98a4e2691f61

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. N. Suzuki
2. Gad Miller
3. R. Mittler
4. M. Juhaszova
5. Caihong Pang
6. Baoshan Wang
7. Sarvajeet S. Gill
8. Sultan Ciftci-Yilmaz

In Neurology

1. M. Brand
2. M. Yorek
3. W. Sivitz

In Physiology

1. Laura Bordone
2. W. Sivitz
3. M. Yorek
4. M. Brand
5. Eyal Gottlieb
6. Narendra Kumar Tuteja
7. L. Guarente
8. M. Juhaszova

Citations in the corpus

• Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “Furthermore, dysregulation, and specifically upregulation, of metabolism-derived H2O2 may play an important role in certain disorders such as aging (38, 175).”
• Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, positive): “These include conversion of superoxide to H 2 O 2 by manganese superoxide dismutase (MnSOD) and scavenging of H 2 O 2 by catalase, glutathione peroxidase (GPX), or peroxiredoxin III (117).”
• Oxidative Stress and Salt Tolerance in Plants (2008, background): “In the course of electron transport reactions in the respiratory chain, ubisemiquinone (UQ10) species donate electrons to oxygen and provide a constant source of O 2 − (Raha and Robinson 2000).”
• Calorie restriction, SIRT1 and metabolism: understanding longevity (2005, background): “In eukaryotes, mitochondria are the prime site of ROS generation, because complex I and complex III of the ELECTRON-TRANSPORT CHAIN occasionally generate these toxic by-products during normal respiratio”
• Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. (2014, background): “Typically, complex II is excluded from the list of potential candidates for important physiological contributors of ROS (347, 348, 358).”
• The sites and topology of mitochondrial superoxide production (2010, background): “…to produce ROS are at complex I (site IQ) and complex III (site IIIQo) (Barja, 1999; Chen et al., 2003; Kudin et al., 2004; Liu et al., 2002; Raha and Robinson, 2000; St-Pierre et al., 2002; Votyakova and Reynolds, 2001), although the other five sites also have significant maximum rates…”
• Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. (2001, background): “In agree-(Raha et al., 2000; Raha and Robinson, 2000).”