Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

By Jinliu Feng, F. Bussière, S. Hekimi. Developmental Cell, 2001

666 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/216ddf184fbdf77d1a42c422c7b3203d35fbd2fa

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Citations in the corpus

Trends in oxidative aging theories. (2007, background): “Mutations in isp-1 (Rieske iron-sulfur protein of Complex III [83]) and clk-1[84] (defective in ubiquinone biosynthesis [85]), presumed to have decreased mitochondrial superoxide production, also show extended life span [84,86,87].”
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity (2003, background): “or electron-transport complex III ( isp-1 ) have been identifie”
Resveratrol improves health and survival of mice on a high-calorie diet (2006, neutral): “3)* Fasted IGF-I (ng ml(21)) 346 (40) 534 (12){ 482 (21){{ Fed 625 (33) 999 (102){ 929 (81){ Fasted IGFBP-1 (AU) 1.”
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, neutral): “Many environmental conditions, in particular stresses, and genetic mutations have been shown to induce sod-3 transcription (Feng et al., 2001; Honda and Honda, 2001; Yanase et al., 2002; Henderson et al., 2006; Wolf et al., 2008; Dingley et al., 2010; González-Cabo et al., 2011; Erkut et al., 2013; ”
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. (2004, methodology): “Dauer assays, high-temperature treatment, measurements of brood size, and behavioral assays were performed as described (Lithgow et al. 1994; Apfeld and Kenyon 1999; Feng et al. 2001).”
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, neutral): “A modification to this theory has suggested alternatively that, because reactive oxygen species (ROS) are generated as a byproduct of the metabolic activity of the mitochondrial ETC during the production of ATP (Harman, 1956), a decrease in ROS production is the major contributing factor to the long”
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “Mitochondrial respiration, like translation, is a major cellular process linked to growth, and reducing respiration in C. elegans extends lifespan ( Feng et al., 2001; Dillin et al., 2002; Lee et al., 2003).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Although mice heterozygous for the Mn- SOD mutation live to old age, they have a chronically reduced liver mitochondrial membrane potential, reduced state III respiration equivalent to that of an old animal, and a striking rise in mitochondrial lipid peroxidation by middle age that drops to below th”
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002, background): “In animals, respiration is essential for viability and mutations that reduce electron transport slow glycolysis and development and also lengthen lifespa”