Allostasis and Allostatic Load: Implications for Neuropsychopharmacology

By Bruce S. McEwen. Neuropsychopharmacology, 2000

1,776 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/975d960faabfe8a9aefcfb0eb929d0688a6136c0

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In Behavioral Neuroscience

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Citations in the corpus

Are Flexible Work Arrangements Associated with Lower Levels of Chronic Stress-Related Biomarkers? A Study of 6025 Employees in the UK Household Longitudinal Study (2019, background): “Allostasis is the physiological process that enables recovery from social and environmental shocks and stressors (McEwen, 2000).”
Effects of forest fragmentation on the physiological stress response of black howler monkeys (2007, background): “…hormones can have negative effects on the health of an organism, suppressing proper functioning of the immune system, promoting severe protein loss (muscle wasting), inhibiting growth, producing neurone cell death and inhibiting reproductive functions (Sapolsky & Pulsinelli, 1985; McEwen, 2000).”
Sleep State Switching (2010, background): “These situations have been called allostatic loads by McEwen and colleagues (McEwen, 2000), and they require additional circuitry for modifying wakesleep cycles.”
Addiction and the brain antireward system. (2008, background): “Allostatic load is the consequence of repeated deviations from homeostasis that take on the form of changed set points that require increasing amounts of energy to defend, and ultimately reach, the level of pathology (McEwen 2000).”
The Reactive Scope Model - a new model integrating homeostasis, allostasis, and stress. (2009, positive): “The Allostatic Model has been used recently to explain why individuals are more susceptible to stress in humans of lower socioeconomic status (SES) (McEwen, 2000).”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “Y Y Psychosocial challenge in the visible burrow system with rats 14 days Plasma corticosterone levels in dominants and subordinates [ Plasma CBG levels in subordinates Y Plasma testosterone levels in subordinates Y 5 - HT 1A receptor in DG and CA1 in dominants and subordinates Y 5 - HT 2 receptor i”
Multiple environmental burdens and neighborhood-related health of city residents (2012, positive): “When this state of ‘allostatic load’ (McEwen, 2000) coincides with other risk factors such as higher age, low social status or low social support (Picket & Pearl, 2001; Wills & Fegan, 2001), the risk of stress-related symptoms enhances (e.g., retarded speed of disease recovery, susceptibility to…”
Alcoholism: allostasis and beyond. (2003, background): “The concept of allostatic load was introduced, which is the price the body pays to adapt to adverse psychosocial or physical situations (McEwen, 2000).”
Stress in Yucatan spider monkeys: effects of environmental conditions on fecal cortisol levels in wild and captive populations (2009, background): “For instance, long-term high levels of cortisol can have negative effects on the health of an organism by inhibiting growth, suppressing the functioning of the immune system or inhibiting reproductive functions (Sapolsky & Pulsinelli, 1985; Sapolsky, 1990; McEwen, 2000; DeVries, 2002).”
THE CONCEPT OF ALLOSTASIS: COPING WITH A CAPRICIOUS ENVIRONMENT (2005, background): “The concept of allostasis, stability through change (McEwen 2000; Schulkin 2003; Sterling and Eyer 1988), is a theoretical framework that can integrate the metabolic demands of normal life-history stages (predictable life cycle) and those caused by perturbations of the environment (unpredictable).”