Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli.

By M. Di Nicola, C. Carlo-Stella, M. Magni, M. Milanesi, P. Longoni, P. Matteucci, S. Grisanti, A. Gianni. Blood, 2002

3,206 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/96fed8b6742b2b5c5c809cb17001b951f1e04666

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. W. Fibbe
2. A. Caplan
3. Maria Ester Bernardo
4. N. Singer
5. R. Lee
6. O. Ringdén
7. Aline M. Betancourt
8. Ruth S. Waterman

In Immunology

1. W. Fibbe
2. Maria Ester Bernardo
3. S. Lim
4. Aline M. Betancourt
5. Vito Pistoia
6. C. Théry
7. Ruth S. Waterman
8. S. Pluchino

In Oncology

1. A. Caplan
2. Hanns-Ulrich Marschall
3. O. Ringdén

Citations in the corpus

• Mesenchymal stem cells in health and disease (2008, background): “The effects of MSCs on immune cells The immunomodulatory effect of MSCs has only been described recently, following the observation that bone-marrow-derived MSCs suppressed T-cell proliferatio”
• Mechanisms of mesenchymal stem/stromal cell function (2016, methodology): “[31] employed a series of antibody blocking assays to implicate the role of transforming growth factor beta (TGFβ) and hepatocyte growth factor (HGF) whereas Aggarwal et al.”
• Mesenchymal stem cell perspective: cell biology to clinical progress (2019, result): “Contemporaneous with early MSC/hematopoietic stem cell transplant clinical studies, in vitro studies tested allo-MSCs in mixed donor lymphocyte reactions and revealed the MSCs prevented lymphocyte proliferation, and do not cause apoptosis of T cells, rather the T cells will respond to subsequent lym”
• Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells (2003, background): “A recent study suggests that the immune modulatory effect of MSCs is caused by their secretion of transforming growth factor- 1 and hepatocyte growth factor, because the use of neutralizing monoclonal antibodies against these factors abolished the suppressive effects on T cells (15).”
• Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “found that MSCs inhibit proliferation of CD4+ and CD8+ T cells [78].”
• Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study (2010, background): “Mesenchymal stromal cells (MSCs) are non-haematopoietic stromal cells exhibiting multi-lineage differentiation capacity and the ability to mediate immunosuppressive and anti-inflammatory effects.”
• Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, positive): “MSCs are able to suppress in vitro T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli (Di Nicola et al., 2002) through the secretion of soluble factors that include TGF-b, Hepatocyte Growth Factor (HGF), PGE2, IDO, NO, and hemoxygenase (HO) (Stagg and Galipeau 2013).”
• T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. (2005, background): “It has been reported that TGF-b and HGF secreted by MSCs function synergistically to suppress T cell proliferation [ 14 ].”