Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells

By I. Rasmusson, O. Ringdén, B. Sundberg, K. Le Blanc. Transplantation, 2003

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Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “Furthermore, any attenuation on NK function that might occur when MSC ligands bind to NK-stimulatory receptors occurs at such a low level that the binding of MHC class I molecules to Kir family–inhibitory NK receptors probably tips the balance in favor of tolerance (rather than cytotoxicity) of NK c”
Mesenchymal stem cells in health and disease (2008, background): “MSCs have been shown to downregulate CTL-mediated cytotoxicit”
Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis (2010, background): “Mesenchymal stem cells have been shown to possess immunomodulating properties, inducing suppression of various immune cell populations.(7-14) Mesenchymal stem cells cultivated under different culture manipulations (chemical induction or use of growth factors) can give rise to neural-like, glial-like”
Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease (2006, methodology): “MSC did not inhibit NKmediated lysis of K562 cells (29).”
Mesenchymal stem cells avoid allogeneic rejection (2005, background): “This effect appeared to be mediated by soluble factors[50,59].”