Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells

By Priscilla N. Kelly, Aleksandar Dakic, Jerry M. Adams, S. Nutt, A. Strasser. Science, 2007

885 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/96487d508a05f50cbe444bfc55edad8171cf1b5e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. K. Polyak
2. Jane E. Visvader
3. Howard Y. Chang
4. M. Clarke
5. J. P. Thiery
6. R. Huang
7. A. Marusyk
8. S. Morrison

In Oncology

1. R. Weinberg
2. Jane E. Visvader
3. M. Nieto
4. Hans Clevers
5. J. P. Thiery
6. K. Polyak
7. S. Morrison
8. G. Lindeman

In Surgery

1. M. Nieto
2. J. P. Thiery
3. Eric R. Fearon
4. Hans Clevers
5. H. Acloque

Citations in the corpus

• Cancer stem cells in solid tumours: accumulating evidence and unresolved questions (2008, background): “have shown that >10% of cells in three mouse models of leukaemia or lymphoma have tumour-regenerating capacity, suggesting that these are maintained by a dominant cell populatio”
• The cancer stem cell: premises, promises and challenges (2011, background): “Indeed, when the species barrier is avoided by transplanting mouse tumor cells into fully histocompatible recipient mice, the efficiency of engraftment can be dramatically improve”
• let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, background): “In fact, when mouse lymphoma cells generated in Em-c-myc transgenic mice are transplanted into congenic mice, lymphoma cells lacking stem cell markers also form tumors (Kelly et al., 2007).”
• Module map of stem cell genes guides creation of epithelial cancer stem cells. (2008, background): “The concept of cancer stem cells has recently been challenged by the observation of frequent (>1/10) tumor-initiating cells in murine lymphoma (Kelly et al., 2007); interestingly, the strongest effect came from the Em-Myc model.”
• Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “We note that recently, the existence and relevance of the prospective isolation of cancer stem cells have been challenged (Kelly et al., 2007).”
• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells (2009, background): “In transgenic mouse models of lymphoma and leukemia, it has been reported that more than 10% of tumor cells are tumor-initiating, suggesting that T-IC are not rare (16).”
• Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy (2008, background): “Although the relevance of these, and all, xenografts to patient tumors has been questioned [5–7], transplantation of human cells into mice is the only model system that does not expose human cells to an aphysiological ex vivo environment comprised of tissue culture plastic and culture medium and whi”
• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “A recent short report has provided evidence that in mouse-to-mouse transplantation using preB/B lymphoma cells from Eμ-myc transgenic mice, most of the cells within mouse tumors retain the CSC phenotype [41].”