Protease‐activated receptors in hemostasis, thrombosis and vascular biology

By S. Coughlin. Journal of Thrombosis and Haemostasis, 2005

1,041 citations recorded by the source corpus.

Subfields: Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/962c8d40383b8e9b5069ac50f0e3be44907b06c5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. H. Versteeg
2. Xi Wang
3. Pieter H. Reitsma
4. R. Khalil
5. S. Verma
6. J. Heemskerk
7. M. Levi
8. N. Mackman

In Hematology

1. H. Versteeg
2. Xi Wang
3. Pieter H. Reitsma
4. R. Khalil
5. S. Verma
6. J. Heemskerk
7. M. Levi
8. N. Mackman

Citations in the corpus

• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “PAR-1 is expressed on a number of different types of cells including endothelial cells, platelets, leukocytes and smooth muscle cells (McNamara et al., 1993; Coughlin, 2000), and is an important target for MMP-1 and MMP-13 (Coughlin, 2001; Macfarlane et al., 2001; Coughlin, 2005).”
• New fundamentals in hemostasis. (2013, background): “Furthermore, GPIb-V-IX binds with high affinity to thrombin, which can support thrombin-induced activation of the receptors PAR1 and PAR4, although the physiological importance of the GPIb pathway is debated (68).”
• The Pathogenesis of Sepsis (2011, background): “there is a rationale for inhibiting thrombin during sepsis, because thrombin plays a major role in inflammation via protease-activated receptors (PARs) (62), the use of thrombin inhibitors during the fulminant coagulopathy of severe sepsis is probably too little, too late.”
• Triggers, targets and treatments for thrombosis (2008, background): “A major pathway of activation involves the cleavage and, consequently, the activation of the platelet receptor PAR1 (protease-activated receptor 1; also known as the thrombin receptor) by the protease thrombin (also known as factor II”
• Inflammation and Pregnancy (2006, background): “In addition to mediating hemostasis via its extracellular proteolytic action, thrombin also induces an array of biological effects in cells that express protease-activated surface receptors (PARs).(63) The interactive effects of a fibrillar collagen-rich extracellular matrix (ECM) of the amnion and ”
• Endothelial cell control of thrombosis (2015, background): “Endothelial PARs serve as sensors for proteases and initiate a cascade of cell signals upon activation by thrombin, APC, fXa, the TF/fVIIa/fXa complex, high concentrations of plasmin, and matrix metalloproteases [69–71].”