New fundamentals in hemostasis.

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Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant–anticoagulant equilibrium toward thrombosis (2017, background): “Blood coagulation is a finely regulated physiological process that culminates with the factor Xa-mediated conversion of the prothrombin (ProT)(3) zymogen to the active -thrombin ( T) enzyme, which in turn is responsible for the generation of insoluble fibrin and activation of platelets via the GpIb ”
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 (2020, background): “Platelets contain a set of coagulation factors and inflammatory factors, stored in the α-granules that are released upon activation to potentiate the coagulation cascade [82, 83].”
The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors (2017, neutral): “1a-b and Supplementary Video 1).”
Endothelial cell control of thrombosis (2015, background): “Since the blood coagulation system is a potent, highly effective process, tight regulation of the blood coagulation system is essential to prevent unnecessary clot formation [18].”